Sepsis, apoptosis and complement
نویسندگان
چکیده
منابع مشابه
Sepsis and complement
Th e complement system is a crucial part of the body’s defense mechanism against bacterial infection and is vital for protecting individuals against any disturbance of homeostasis associated with the appearance of foreign antigens [1]. Activation of the complement system can be initiated through the classic pathway antigen-antibody complexes or through the alternative and lectin pathways by non...
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Sepsis in human beings is a major problem involving many individuals and with a high death rate. Except for a single drug (recombinant activated protein C) that has been approved for treatment of septic patients, supportive measures represent the main clinical approach. There are many models of experimental sepsis, mostly in rodents. A commonly used model is cecal ligation and puncture (CLP). I...
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Sepsis remains a poorly understood, enigmatic disease. One of the cascades crucially involved in its pathogenesis is the complement system. Especially the anaphylatoxin C5a has been shown to have numerous harmful effects during sepsis. We have investigated the impact of high levels of C5a on the adrenal medulla following cecal ligation and puncture (CLP)-induced sepsis in rats as well as the ro...
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Objective: To provide a series of recommendations, based on the best available evidence, to guide clinicians providing nursing care to patients with severe sepsis. Design: Modified Delphi method involving international experts and key individuals in subgroup work and electronic-based discussion among entire group to achieve consensus. Methods: We used the Surviving Sepsis Campaign Guidelines (S...
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The complement system is one of the key players in the defence against infections. Its activation during the innate immune response leads to the generation of several proteins that contribute to the lysis and opsonization of microorganisms, regulate inflammatory reactions and bridge innate immunity with the subsequent adaptive immune response. Complement is also activated in overwhelming bacter...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2008
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2008.09.017